Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields

Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields Full article

Journal

Magnetochemistry
ISSN: 2312-7481

Output data

Year: 2025, Volume: 11, Number: 9, Article number : 80, Pages count : 16 DOI: 10.3390/magnetochemistry11090080

Authors

Wibbels Garrett L. ^1,2 , Oladun Clementinah ³ , O’Hara Tanner Y. ^2,4 , Adelabu Isaiah ³ , Robinson Joshua E. ^2,4 , Ahmed Firoz ³ , Bender Zachary T. ^2,5 , Samoilenko Anna ³ , Gyesi Joseph ³ , Kovtunova Larisa M. ⁶ , Salnikov Oleg G. ⁶ , Koptyug Igor V. ⁶ , Goodson Boyd M. ⁷ , Snow W.Michael ⁸ , Chekmenev Eduard Y. ³ , Shchepin Roman V. ²

Affiliations

1	Department of Chemical and Biological Engineering, and Health Sciences, South Dakota School of Mines & Technology, Rapid City, SD 57701, USA
2	Department of Chemistry, Biology, and Health Sciences, South Dakota School of Mines & Technology, Rapid City, SD 57701, USA
3	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute, Wayne State University, Detroit, MI 48202, USA
4	Department of Materials and Metallurgical Engineering, South Dakota School of Mines & Technology, Rapid City, SD 57701, USA
5	Department of Nanoscience & Biomedical Engineering, South Dakota School of Mines & Technology, Rapid City, SD 57701, USA
6	International Tomography Center SB RAS, Novosibirsk 630090, Russia
7	School of Chemical & Biomolecular Sciences, Southern Illinois University, Carbondale, IL 62901, USA
8	Department of Physics, Indiana University Bloomington/IU Center for Exploration of Energy and Matter, Bloomington, IN 47408, USA

Hyperpolarization (HP) techniques, such as Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and dissolution Dynamic Nuclear Polarization (d-DNP), significantly enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy for chemical analysis and metabolic imaging. However, the high cost of equipment, ranging from tens of thousands to millions of dollars, limits accessibility of hyperpolarization for the broad scientific community. In this work, we aim to mitigate some of the challenges by developing a cost-effective solution for parahydrogen (pH2)-based PHIP and SABRE HP methods. A custom coil-winding machine was designed to fabricate solenoid magnet coils, which were then evaluated for their magnetic field profiles, demonstrating a high degree of magnetic field homogeneity. A model 1H SABRE experiment successfully implemented the constructed solenoid, achieving efficient hyperpolarization. Additionally, the solenoid magnet can be utilized for in situ detection of hyperpolarization when integrated with a low-field NMR spectrometer, reducing the total setup cost to a few thousand dollars. These findings suggest that our approach makes HP technology more affordable and accessible, potentially broadening its applications in chemical and biomedical research, as well as educational settings involving undergraduate student researchers. This work provides a practical pathway to lower the financial barriers associated with pH2 HP setups.

Wibbels G.L. , Oladun C. , O’Hara T.Y. , Adelabu I. , Robinson J.E. , Ahmed F. , Bender Z.T. , Samoilenko A. , Gyesi J. , Kovtunova L.M. , Salnikov O.G. , Koptyug I.V. , Goodson B.M. , Snow W.M. , Chekmenev E.Y. , Shchepin R.V.
Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields
Magnetochemistry. 2025. V.11. N9. 80 :1-16. DOI: 10.3390/magnetochemistry11090080 WOS OpenAlex

Submitted:	Aug 31, 2025
Accepted:	Sep 18, 2025
Published print:	Sep 22, 2025

Web of science:	WOS:001580416000001
OpenAlex:	W4414410478

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