Abstract: Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI) are analytical and diagnostic tools that are essential for a very broad field of applications, ranging from chemical analytics, to non-destructive testing of materials and the investigation of molecular dynamics, to in vivo medical diagnostics and drug research. One of the major challenges in their application to many problems is the inherent low sensitivity of magnetic resonance, which results from the small energy-differences of the nuclear spin-states. At thermal equilibrium at room temperature the normalized population difference of the spin-states, called the Boltzmann polarization, is only on the order of 10−5. Parahydrogen induced polarization (PHIP) is an efficient and cost-effective hyperpolarization method, which has widespread applications in Chemistry, Physics, Biochemistry, Biophysics, and Medical Imaging. PHIP creates its signal-enhancements by means of a reversible (SABRE) or irreversible (classic PHIP) chemical reaction between the parahydrogen, a catalyst, and a substrate. Here, we first give a short overview about parahydrogen-based hyperpolarization techniques and then review the current literature on method developments and applications of various flavors of the PHIP experiment.

Cite: Buntkowsky G. , Theiss F. , Lins J. , Miloslavina Y.A. , Wienands L. , Kiryutin A. , Yurkovskaya A.
Recent advances in the application of parahydrogen in catalysis and biochemistry
RSC Advances. 2022. V.12. N20. P.12477-12506. DOI: 10.1039/d2ra01346k WOS OpenAlex

Dates:

Submitted:	Feb 28, 2022
Accepted:	Mar 23, 2022
Published online:	Apr 26, 2022

Identifiers:

Web of science:	WOS:000787356100001
OpenAlex:	W4225092843

Citing:

DB	Citing
OpenAlex	50
Web of science	42

Altmetrics: