Abstract: By combining magnetic field cycling in the range from 0.1 mT to 7 T with high-resolution NMR detection, the T1 relaxation dispersion (nuclear magnetic relaxation dispersion (NMRD)) of protons in the nucleotides adenosine monophosphate and guanosine monophosphate was measured in a site-specific way. While at high field the individual spins have distinctly different T1 times, their scalar spin-spin interaction fulfills at low field the condition of strong coupling and leads to convergence of their T1 dispersion curves. In addition, the spin-spin coupling can lead to oscillatory components in the relaxation kinetics traceable to a coupling between spin polarization and coherence in the relaxation process. As a consequence, the NMRD curves do not directly reflect the spectral density function of the motional processes, but the effects of motion and spin coupling must be separated for a reliable evaluation. A theoretical approach is described that allows such an analysis.

Cite: Kiryutin A. , Ivanov K. , Yurkovskaya A. , Vieth H-M.
High-resolution study of nuclear magnetic relaxation dispersion of purine nucleotides: Effects of spin-spin coupling
Solid State Nuclear Magnetic Resonance. 2008. V.34. N1-2. P.142-149. DOI: 10.1016/j.ssnmr.2008.03.004 OpenAlex

Dates:

Submitted:	Jan 21, 2008
Published online:	Mar 13, 2008

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W2078380514

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