Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives Научная публикация

Журнал

International Journal of Molecular Sciences
ISSN: 1661-6596

Вых. Данные

Год: 2023, Том: 24, Номер: 1, Номер статьи : 557, Страниц : 9 DOI: 10.3390/ijms24010557

Ключевые слова

heteroatomic nuclei, hyperpolarization, hyperpolarized probe, magnetic resonance imaging, NMR spectroscopy, 31P nucleus, parahydrogen, polarization transfer, phosphates, signal amplification

Авторы

Zlobina Veronika V. ^1,2 , Kiryutin Alexey S. ^3,4 , Nikovskiy Igor A. ¹ , Artyushin Oleg I. ¹ , Kozinenko Vitaly P. ^3,4 , Peregudov Alexander S. ¹ , Yurkovskaya Alexandra V. ^3,4 , Novikov Valentin V. ^2,5

Организации

1	Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova Str. 28, 119991 Moscow, Russia
2	Moscow Institute of Physics and Technology, National Research University, Institutskiy per. 9, 141700 Dolgoprudny, Russia
3	International Tomography Center, Siberian Branch of the Russian Academy of Sciences, Institutskaya Str. 3A, 630090 Novosibirsk, Russia
4	Department of Physics, Novosibirsk State University, Pirogova Str. 2, 30090 Novosibirsk, Russia
5	BMSTU Center of National Technological Initiative “Digital Material Science: New Material and Substances”, Bauman Moscow State Technical University, 2nd Baumanskaya Str. 5, 105005 Moscow, Russia

Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.

Zlobina V.V. , Kiryutin A.S. , Nikovskiy I.A. , Artyushin O.I. , Kozinenko V.P. , Peregudov A.S. , Yurkovskaya A.V. , Novikov V.V.
Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives
International Journal of Molecular Sciences. 2023. V.24. N1. 557 :1-9. DOI: 10.3390/ijms24010557 WOS Scopus OpenAlex

Поступила в редакцию:	5 дек. 2022 г.
Принята к публикации:	27 дек. 2022 г.
Опубликована online:	29 дек. 2022 г.

Web of science:	WOS:000909472200001
Scopus:	2-s2.0-85145885292
OpenAlex:	W4313328747

БД	Цитирований
Web of science	2
OpenAlex	2
Scopus	2