Total Correlation Spectroscopy across All NMR-Active Nuclei by Mixing at Zero Field

Total Correlation Spectroscopy across All NMR-Active Nuclei by Mixing at Zero Field Научная публикация

Журнал

The Journal of Physical Chemistry Letters
ISSN: 1948-7185

Вых. Данные

Год: 2020, Том: 11, Номер: 17, Страницы: 7291-7296 Страниц : 6 DOI: 10.1021/acs.jpclett.0c02032

Авторы

Zhukov Ivan V. ^1,2 , Kiryutin Alexey S. ^1,2 , Ferrage Fabien ^3,4 , Buntkowsky Gerd ⁵ , Yurkovskaya Alexandra V. ^1,2 , Ivanov Konsrantin L. ^1,2

Организации

1	International Tomography Center SB RAS, Novosibirsk 630090, Russia;
2	Novosibirsk State University, Novosibirsk 630090, Russia
3	Laboratoire des Biomolécules, Département de Chimie, École Normale Supérieure, PSL University
4	Sorbonne Université, CNRS
5	Institute of Inorganic and Physical Chemistry, Technical University of Darmstadt, D-64287 Darmstadt, Germany

Multidimensional nuclear magnetic resonance (NMR) is based on a combination of well-established building blocks for polarization transfer. These blocks are used to design correlation experiments through one or a few chemical bonds or through space. Here, we introduce a building block that enables polarization transfer across all NMR-active nuclei in a coupled network of spins: isotropic mixing at zero and ultralow field (ZULF). Exploiting mixing under ZULF-NMR conditions, heteronuclear TOtal Correlation SpectroscopY (TOCSY) experiments were developed to highlight coupled spin networks. We demonstrate 1H–13C and 1H–15N correlations in ZULF–TOCSY spectra of labeled amino acids, which allow one to obtain cross-peaks among all heteronuclei belonging to the same coupled network, even when the direct interaction between them is negligible. We also demonstrate the potential of ZULF–TOCSY to analyze complex mixtures on a growth medium of isotope-labeled biomolecules. ZULF–TOCSY enables the quick identification of individual compounds in the mixture by their coupled spin networks. The ZULF–TOCSY method will lead to the development of a new toolbox of experiments to analyze complex mixtures by NMR.

Zhukov I.V. , Kiryutin A.S. , Ferrage F. , Buntkowsky G. , Yurkovskaya A.V. , Ivanov K.L.
Total Correlation Spectroscopy across All NMR-Active Nuclei by Mixing at Zero Field
The Journal of Physical Chemistry Letters. 2020. V.11. N17. P.7291-7296. DOI: 10.1021/acs.jpclett.0c02032 WOS OpenAlex

Поступила в редакцию:	2 июл. 2020 г.
Принята к публикации:	10 авг. 2020 г.
Опубликована online:	10 авг. 2020 г.

Web of science:	WOS:000569375400051
OpenAlex:	W3048369547

БД	Цитирований
OpenAlex	19