Guest Molecules Release from MOF-808 and MOF-Based Hydrogel: An EPR Study | Sciact

Guest Molecules Release from MOF-808 and MOF-Based Hydrogel: An EPR Study Научная публикация

Журнал

The Journal of Physical Chemistry C
ISSN: 1932-7447

Вых. Данные

Год: 2025, Том: 129, Номер: 49, Страницы: 21878–21886 Страниц : 9 DOI: 10.1021/acs.jpcc.5c06713

Авторы

Yazikova Anastasiya A. ^1,2 , Tomilov Aleksandr S. ^1,2 , Livanovich Kanstantsin S. ³ , Smirnova Kristina A. ^1,2 , Kirilyuk Igor A. ⁴ , Polienko Yuliya F. ⁴ , Poryvaev Artem S. ¹ , Fedin Matvey V. ^1,2

Организации

1	International Tomography Center SB RAS, Institutskaya Str. 3a, 630090 Novosibirsk, Russia
2	Novosibirsk State University, Pirogova Str. 2, 630090 Novosibirsk, Russia
3	Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, F.Skaryna str., 36, Minsk 220141, Belarus
4	Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia

Precise, long-term control of drug concentration in organs and tissues of patients remains a significant challenge in modern pharmaceutics. In this work we investigate the metal–organic framework MOF-808, both in its pristine form and incorporated into a carboxymethylcellulose/chitosan (CMC-chitosan) hydrogel polyelectrolyte dressing, as a prospective platform for controlled drug release. Using electron paramagnetic resonance (EPR) spectroscopy and spin probes (radicals) that model drug molecules, we demonstrate that the controllable release kinetics from MOF-808 into water strongly depends on the functional groups of the released guests. The MOF-808 effectively functions as a reservoir, maintaining a stable target concentration of guest molecules in practical water volumes. Furthermore, embedding the MOF particles into CMC-chitosan hydrogel creates convenient platform for practical applications. Although conjugation of MOF-808 and hydrogel leads to an extra release of the cargo radicals, upon their elimination the release profile approaches that of the pristine MOF-808. This study underscores the potential of MOF-808 for sustained drug release applications and highlights critical considerations for its integration into composite hydrogel materials using EPR spectroscopy as the primary investigative tool.

Yazikova A.A. , Tomilov A.S. , Livanovich K.S. , Smirnova K.A. , Kirilyuk I.A. , Polienko Y.F. , Poryvaev A.S. , Fedin M.V.
Guest Molecules Release from MOF-808 and MOF-Based Hydrogel: An EPR Study
The Journal of Physical Chemistry C. 2025. V.129. N49. P.21878–21886. DOI: 10.1021/acs.jpcc.5c06713 WOS OpenAlex

Опубликована в печати:

11 дек. 2025 г.

Web of science:	WOS:001627271800001
OpenAlex:	W4416770929

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