The application of novel Ir-NHC polarization transfer complexes by SABRE

The application of novel Ir-NHC polarization transfer complexes by SABRE Full article

Journal

The Journal of Chemical Physics
ISSN: 0021-9606

Output data

Year: 2019, Volume: 151, Number: 24, Article number : 244201, Pages count : 7 DOI: 10.1063/1.5128091

Authors

Hadjiali Sara ¹ , Bergmann Marvin ¹ , Kiryutin Alexey ^2,5 , Knecht Stephan ¹ , Sauer Grit ¹ , Plaumann Markus ³ , Limbach Hans-Heinrich ^1,4 , Plenio Herbert ¹ , Buntkowsky Gerd ¹

Affiliations

1	Eduard-Zintl Institute for Inorganic and Physical Chemistry, TU Darmstadt, Darmstadt 64287, Germany
2	International Tomography Center, Institutskaya 3A, Novosibirsk
3	Medical Faculty, Institute for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany
4	Freie Universität Berlin, Institut für Chemie und Biochemie, Takustr. 3, D-14195 Berlin, Germany
5	Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia

In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated.

Hadjiali S. , Bergmann M. , Kiryutin A. , Knecht S. , Sauer G. , Plaumann M. , Limbach H-H. , Plenio H. , Buntkowsky G.
The application of novel Ir-NHC polarization transfer complexes by SABRE
The Journal of Chemical Physics. 2019. V.151. N24. 244201 :1-7. DOI: 10.1063/1.5128091

Submitted:	Sep 16, 2019
Accepted:	Dec 4, 2019
Published online:	Dec 23, 2019

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