Efficient conversion of anti-phase spin order of protons into 15N magnetisation using SLIC-SABRE

Efficient conversion of anti-phase spin order of protons into 15N magnetisation using SLIC-SABRE Научная публикация

Журнал

Molecular Physics
ISSN: 0026-8976

Вых. Данные

Год: 2019, Том: 117, Номер: 19, Страницы: 2762–2771 Страниц : 10 DOI: 10.1080/00268976.2018.1515999

Ключевые слова

Spin hyperpolarisation, parahydrogen, SABRE method, spin order, polarisation transfer

Авторы

Knecht Stephan ^1,2,3 , Kiryutin Alexey S. ^4,5 , Yurkovskaya Alexandra V. ^4,5 , Ivanov Konstantin L. ^4,5

Организации

1	Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Darmstadt, Germany
2	Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
3	Molecular Imaging North Competence Center (MOIN CC), Section for Biomedical Imaging, Department for Radiology and Neuroradiology, University Medical Center Schleswig Holstein (UKSH), University of Kiel, Kiel, Germany
4	International Tomography Center, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russia
5	Novosibirsk State University, Novosibirsk, Russia

ABRE (Signal Amplification By Reversible Exchange) is a technique for enhancement of NMR (Nuclear Magnetic Resonance) signals, which utilises parahydrogen (pH2, the H2 molecule in its nuclear singlet spin state) as a source of non-thermal spin order. In SABRE experiments, pH2 binds transiently to an organometallic complex with a to-be-polarised substrate; subsequently, spin order transfer takes place and the substrate acquires non-thermal spin polarisation resulting in strong NMR signal enhancement. In this work, we argue that the spin order of H2 in SABRE experiments performed at high magnetic fields is not necessarily the singlet order but rather anti-phase polarisation, S1⁢z⁢S2⁢z. Although SABRE exploits pH2, i.e. the starting spin order of H2 is supposed to be the singlet order, in solution, S−T0 conversion becomes efficient once pH2 binds to a complex. Such a variation of the spin order, which becomes S1⁢z⁢S2⁢z, has an important consequence: NMR methods used for transferring SABRE polarisation need to be modified. Here we demonstrate that methods proposed for the initial singlet order may not work for the S1⁢z⁢S2⁢z order; however, a simple modification makes them efficient again.

Knecht S. , Kiryutin A.S. , Yurkovskaya A.V. , Ivanov K.L.
Efficient conversion of anti-phase spin order of protons into 15N magnetisation using SLIC-SABRE
Molecular Physics. 2019. V.117. N19. P.2762–2771. DOI: 10.1080/00268976.2018.1515999

Поступила в редакцию:	24 февр. 2018 г.
Принята к публикации:	14 авг. 2018 г.
Опубликована online:	5 сент. 2018 г.

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