Magnetic field effect in natural cryptochrome explored with model compound

Magnetic field effect in natural cryptochrome explored with model compound Full article

Journal

Scientific Reports
ISSN: 2045-2322

Output data

Year: 2017, Volume: 7, Number: 1, Article number : 11892, Pages count : 10 DOI: 10.1038/s41598-017-10356-4

Authors

Paul Shubhajit ¹ , Kiryutin Alexey S. ^2,3 , Guo Jinping ⁴ , Ivanov Konstantin L. ^2,3 , Matysik Jörg ¹ , Yurkovskaya Alexandra V. ^2,3 , Wang Xiaojie ⁴

Affiliations

1	Institut für Analytische Chemie, Universität Leipzig, Linnéstr, 3, D-04103, Leipzig, Germany
2	International Tomography Center, Siberian Branch of the Russian Academy of Science, Institutskaya 3a, Novosibirsk, 630090, Russia
3	Novosibirsk State University, Pirogova 2, Novosibirsk, 630090, Russia
4	Department of Chemistry and Biology, College of Science, National University of Defense Technology, 410073, Changsha, China

Many animals sense the Earth’s magnetic-field and use it for navigation. It is proposed that a light-dependent quantum effect in cryptochrome proteins, residing in the retina, allows for such an iron-free spin-chemical compass. The photochemical processes, spin-dynamics and its magnetic field dependence in natural cryptochrome are not fully understood by the in vivo and in vitro studies. For a deeper insight into these biophysical mechanisms in cryptochrome, we had introduced a flavin-tryptophan dyad (F10T). Here we present the magnetic field dependence of 1H photo-CIDNP NMR on F10T and a theoretical model for low-field photo-CIDNP of F10T. This model provides mixing mechanism of energy-levels and spin-dynamics at low magnetic fields. Photo-CIDNP has been observed even at Earth’s magnetic field (~0.05 mT). These experiments prove F10T to be an excellent model compound establishing the key mechanism of avian-magnetoreception and provide insight into the optimal behaviour of cryptochrome at Earth’s magnetic field.

Paul S. , Kiryutin A.S. , Guo J. , Ivanov K.L. , Matysik J. , Yurkovskaya A.V. , Wang X.
Magnetic field effect in natural cryptochrome explored with model compound
Scientific Reports. 2017. V.7. N1. 11892 :1-10. DOI: 10.1038/s41598-017-10356-4

Submitted:	Jun 6, 2017
Accepted:	Aug 2, 2017
Published online:	Sep 19, 2017

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