Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution

Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution Full article

Journal

The Journal of Physical Chemistry C
ISSN: 1932-7447

Output data

Year: 2017, Volume: 121, Number: 8, Pages: 4481-4487 Pages count : 7 DOI: 10.1021/acs.jpcc.7b00509

Authors

Burueva Dudari B. ^1,2 , Romanov Alexey S. ^1,2 , Salnikov Oleg G. ^1,2 , Zhivonitko Vladimir V. ^1,2 , Chen Yu-Wen ³ , Barskiy Danila A. ^4,5 , Chekmenev Eduard Y. ^4,5,6 , Hwang Dennis W. ³ , Kovtunov Kirill V. ^1,2 , Koptyug Igor V. ^1,2

Affiliations

1	International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia
2	Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia
3	Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Road, Min-Hsiung, Chiayi 62102, Taiwan
4	Department of Biomedical Engineering and Physics, Vanderbilt-Ingram Cancer Center (VICC), 1301 Medical Center Drive, Nashville, Tennessee 37232-2310, United States
5	Department of Radiology, Vanderbilt University Institute of Imaging Science (VUIIS), 1161 21st Avenue South, Medical Center North, AA-1105, Nashville, Tennessee 37232-2310, United States
6	Russian Academy of Sciences, 14 Leninskiy Prospekt, 119991 Moscow, Russia

Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin–lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6 or methanol-d4). The approximate values of the HP decay time for propane dissolved in acetone-d6 are 35.1 and 28.6 s for the CH2 group and the CH3 group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propane T1 value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.

Burueva D.B. , Romanov A.S. , Salnikov O.G. , Zhivonitko V.V. , Chen Y-W. , Barskiy D.A. , Chekmenev E.Y. , Hwang D.W. , Kovtunov K.V. , Koptyug I.V.
Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution
The Journal of Physical Chemistry C. 2017. V.121. N8. P.4481-4487. DOI: 10.1021/acs.jpcc.7b00509 WOS Scopus

Submitted:	Jan 17, 2017
Accepted:	Feb 6, 2017
Published online:	Feb 20, 2017
Published print:	Mar 2, 2017

Web of science:	WOS:000395616200042
Scopus:	2-s2.0-85020384901

DB	Citing
Scopus	17
Web of science	17