Anion influence on the structure and cytotoxicity of Copper(II) complexes based on 2,2’-bipyridine/1,10-phenanthroline and benzimidazole derivative

Anion influence on the structure and cytotoxicity of Copper(II) complexes based on 2,2’-bipyridine/1,10-phenanthroline and benzimidazole derivative Full article

Journal

Inorganica Chimica Acta
ISSN: 0020-1693

Output data

Year: 2025, Volume: 587, Article number : 122803, Pages count : DOI: 10.1016/j.ica.2025.122803

Authors

Golubeva Yu.A. ¹ , Ermakova E.A. ¹ , Smirnova K.S. ¹ , Klyushova L.S. ² , Zaytsev N.P. ³ , Osik N.A. ⁴ , Berezin A.S. ¹ , Potapov A.S. ¹ , Lider E.V. ¹

Affiliations

1	Nikolaev Institute of Inorganic Chemistry, SB RAS, 3, Acad. Lavrentiev Ave., 630090 Novosibirsk, Russia
2	Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine (FRC FTM), 2/12, Timakova str., 630060 Novosibirsk, Russia
3	Novosibirsk State University, Department of Natural Sciences, 1, Pirogova str., 630090 Novosibirsk, Russia
4	International Tomography Center SB RAS, 3a, Institutskaya, 630090 Novosibirsk, Russia

Eight new copper(II) coordination compounds have been synthesized by the reactions of Cu(X)2 salts (X = Cl−, Br−, NO3− or ClO4−), 2,2′-bipyridine / 1,10-phenanthroline and 1-(1H-benzimidazol-1-ylmethyl)-1H-1,2,3-benzotriazole (L): [Cu(bipy/phen)LCl2]·H2O (1)/(5), [Cu(bipy/phen)LBr2]·H2O (2)/(6), Cu(bipy)L2(NO3)2(H2O) (3), [Cu(bipy)L2(ClO4)2]·0.4C2H5OH (4), {[Cu(phen)L2(NO3)]NO3·0.5H2O·0.8C2H5OH}n (7), [Cu(phen)L2(MeCN)ClO4]ClO4 (8). The complexes were characterized by CHN, thermogravimetric and high-resolution electrospray mass spectrometric analysis, IR spectroscopy, powder and single-crystal X-ray diffraction. A crystallographic study revealed that Cu:bipy/phen:L ratio, the geometry of the complexes and their nuclearity differ depending on the selected anions. Stability of the complexes in ethanol and phosphate-buffered saline was studied by UV–Vis and EPR spectroscopy. In vitro cytotoxic activity was determined against three tumor cell lines (A549, Hep2, HepG2) and non-tumor lung fibroblasts MRC5. All complexes exhibit dose-dependent cytotoxicity on tumor cells with phenanthroline-based compounds 5–8 being 3–10 times more cytotoxic than medical drug cisplatin.

Golubeva Y.A. , Ermakova E.A. , Smirnova K.S. , Klyushova L.S. , Zaytsev N.P. , Osik N.A. , Berezin A.S. , Potapov A.S. , Lider E.V.
Anion influence on the structure and cytotoxicity of Copper(II) complexes based on 2,2’-bipyridine/1,10-phenanthroline and benzimidazole derivative
Inorganica Chimica Acta. 2025. V.587. 122803 . DOI: 10.1016/j.ica.2025.122803 WOS Scopus

Published print:

Nov 1, 2025

Web of science:	WOS:001510785300001
Scopus:	2-s2.0-105007516739

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