In-Line NMR Diagnostics of Hydroformylation Provided by the Segmented-Flow Microfluidic Regime

In-Line NMR Diagnostics of Hydroformylation Provided by the Segmented-Flow Microfluidic Regime Full article

Journal

Analytical Chemistry
ISSN: 0003-2700

Output data

Year: 2025, Volume: 97, Pages: 27879−27884 Pages count : 6 DOI: 10.1021/acs.analchem.5c05154

Authors

Eid Mahmoud E.A. ^1,2 , Nenasheva Maria V. ³ , Bulgakov Aleksei N. ² , Soldatov Alexander V. ² , Burueva Dudari B. ⁴ , Kononenko Elizaveta S. ^4,5 , Skovpin Ivan V. ⁴ , Koptyug Igor V. ⁴ , Gorbunov Dmitry N. ³ , Guda Alexander A. ²

Affiliations

1	Physics Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt
2	The Smart Materials Research Institute, Sladkova 178/24, 344090 Rostov-on-Don, Russia
3	Faculty of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1/3, 119234 Moscow, Russia
4	International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia
5	Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia

Hydroformylation is an industrial method for the conversion of olefins to aldehydes, which are further transformed to other valuable products, including primary alcohols. In industry, it is catalyzed by Rh and Co complexes, mostly under homogeneous catalysis conditions and in batch mode. The microfluidic regime offers improved mass and heat transfer efficiency due to a large gas–liquid interfacial area in the segmented-flow regime that accelerates conversion and shows increased yields of the products. However, the existing in situ spectroscopic characterization methods either lack sensitivity or require complex preparation steps to separate signals from olefin isomers, aldehydes, and other products formed in the reaction mixture. We employed 1H NMR spectroscopy for fast in-line monitoring of hydroformylation products directly within the segmented flow. This approach avoids the replacement of organic solvents by expensive deuterated analogues as well as sample probing and preparation for ex situ NMR spectroscopy. Our work opens wide perspectives for screening and optimization of hydroformylation under microfluidic conditions.

Eid M.E.A. , Nenasheva M.V. , Bulgakov A.N. , Soldatov A.V. , Burueva D.B. , Kononenko E.S. , Skovpin I.V. , Koptyug I.V. , Gorbunov D.N. , Guda A.A.
In-Line NMR Diagnostics of Hydroformylation Provided by the Segmented-Flow Microfluidic Regime
Analytical Chemistry. 2025. V.97. P.27879−27884. DOI: 10.1021/acs.analchem.5c05154 WOS Scopus OpenAlex

Submitted:	Aug 21, 2025
Accepted:	Dec 10, 2025
Published online:	Dec 14, 2025
Published print:	Dec 23, 2025

Web of science:	WOS:001638331200001
Scopus:	2-s2.0-105025210663
OpenAlex:	W4417305661

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