Potent dual-mode hyperthermia and chemodynamic therapy triggered by smart magnetic ring-shaped nanozymes under switchable T1–T2 MRI navigation

Potent dual-mode hyperthermia and chemodynamic therapy triggered by smart magnetic ring-shaped nanozymes under switchable T1–T2 MRI navigation Full article

Journal

Materials and Design
ISSN: 1873-4197

Output data

Year: 2025, Volume: 258, Article number : 114630, Pages count : 15 DOI: 10.1016/j.matdes.2025.114630

Authors

Hu Ying ¹ , Guo Shuangshuang ² , Liu Jun ³ , Yang Yuhao ² , Wang Jing ⁴ , Chen Miaomiao ² , Zhao Wenqian ⁴ , Fan Dandan ² , Zhuang Yuchuan ⁵ , Li Jing ⁶ , Dong Yanbo ⁷ , Tulupov Andrey ⁸ , Wang Xiao ¹ , Bao Jianfeng ¹

Affiliations

1	Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
2	School of Basic Medical Sciences, Academy of Medical Sciences, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001 Henan, China
3	Department of Anesthesiology and Perioperative Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui 453100 Henan Province, China
4	School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 71000, China
5	Department of Imaging Sciences, University of Rochester Rochester 14627, USA
6	Office of Science and Technology, Henan University of Science and Technology, Luoyang, China
7	Faculty of Teacher Education, Pingdingshan University, Pingdingshan, Henan 467000, China
8	The Laboratory MRT TECHNOLOGIES, The Institute International Tomography Center of the Russian Academy of Sciences, Institutskaya Str. 3A, 630090 Novosibirsk, Russia

Emerging nanotechnologies in cancer therapy increasingly highlight the importance of integrating therapeutic and diagnostic functions into a single platform for enhanced efficacy and real-time monitoring. Here, we present a vortex‐shaped nanoring Fe3O4@MnO2@PDA (polydopamine) engineered for dual‐mode T1–T2 magnetic resonance imaging (MRI)‐guided, dual‐thermal, and Fenton‐like chemodynamic therapy (CDT). The ring‐shaped nano Fe3O4 core provides magnetothermal hyperthermia, while the MnO2 layer, acting as a responsive nanozyme, catalyzes endogenous H2O2 to generate oxygen and bolster CDT. Meanwhile, the PDA coating efficiently absorbs near‐infrared light, amplifying photothermal effects for tumor ablation. Under dual‐heating conditions, the temperature rise rate (2.05–2.92 times) and final equilibrium temperatures (1.57–2.27 times) exceed those of single‐mode heating, underscoring a robust synergistic effect. Additionally, due to the shell’s shielding effect weakening T2 signals and the tumor microenvironment enhancing T1 relaxation, the T1 (5.75 Mm−1 s−1) to T2 (91.56 mM−1 s−1) ratio is optimized specifically at tumor sites, thus achieving effective dual‐modal MRI contrast. Moreover, the smart MnO2 design not only furnishes dynamic imaging enhancements but also enables environment‐triggered Mn2+ release, offering further diagnostic and therapeutic benefits. In vitro and in vivo evaluations confirm significant tumor suppression with minimal systemic toxicity. These findings position nanoring Fe3O4@MnO2@PDA as a promising dual‐mode MRI‐guided, dual‐thermal, and chemodynamic platform for advanced cancer therapy.

Hu Y. , Guo S. , Liu J. , Yang Y. , Wang J. , Chen M. , Zhao W. , Fan D. , Zhuang Y. , Li J. , Dong Y. , Tulupov A. , Wang X. , Bao J.
Potent dual-mode hyperthermia and chemodynamic therapy triggered by smart magnetic ring-shaped nanozymes under switchable T1–T2 MRI navigation
Materials and Design. 2025. V.258. 114630 :1-15. DOI: 10.1016/j.matdes.2025.114630 WOS

Published print:

Sep 1, 2025

Web of science:

WOS:001565518600007

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