Synthesis and analgesic activity of pyrrolidinomorphinan derivatives

Synthesis and analgesic activity of pyrrolidinomorphinan derivatives Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 1573-9031

Output data

Year: 2007, Volume: 41, Number: 2, Pages: 74-77 Pages count : 4 DOI: 10.1007/s11094-007-0016-3

Authors

Shul'ts E.E. ¹ , Tolstikova T.G. ¹ , Tolstikov S.E. ¹ , Daibova V.T. ¹ , Shakirov M.M. ¹ , Bolkunov A.V. ¹ , Dolgikh M.P. ¹

Affiliations

1	Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia

Diels– Alder reactions of (-)-thebaine with N-substituted maleimides have been used to obtain cycloadducts possessing-facial stereoselectivity. The 3-O- and 6-O-demethylated derivatives as well as the products of complete and partial reduction of carbonyl groups in the pyrrolidinedione moiety were also obtained. Some of the synthesized compounds have proved to be promising analgesics. The introduction of the bromine atom into the aryl moiety favors prolongation of the analgesic effect.

Shul'ts E.E. , Tolstikova T.G. , Tolstikov S.E. , Daibova V.T. , Shakirov M.M. , Bolkunov A.V. , Dolgikh M.P.
Synthesis and analgesic activity of pyrrolidinomorphinan derivatives
Pharmaceutical Chemistry Journal. 2007. V.41. N2. P.74-77. DOI: 10.1007/s11094-007-0016-3 Scopus

Submitted:	Sep 5, 2005
Published print:	Feb 1, 2007

Scopus:

2-s2.0-34548575044

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