Chemical Reaction Monitoring using Zero‐Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers

Chemical Reaction Monitoring using Zero‐Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers Full article

Journal

Angewandte Chemie - International Edition
ISSN: 1433-7851

Output data

Year: 2020, Volume: 59, Number: 39, Pages: 17026-17032 Pages count : 7 DOI: 10.1002/anie.202006266

Authors

Burueva Dudari B. ^1,2 , Eills James ^3,4 , Blanchard John W. ⁵ , Garcon Antoine ^3,4 , Picazo‐Frutos Román ^3,4 , Kovtunov Kirill V. ^1,2 , Koptyug Igor V. ^1,2 , Budker Dmitry ^3,6,7

Affiliations

1	Laboratory of Magnetic Resonance Microimaging, International Tomography Center, 630090 Novosibirsk, Russia
2	Novosibirsk State University, 630090 Novosibirsk, Russia
3	Helmholtz Institute Mainz GSI Helmholtzzentrum für Schwerionenforschung GmbH 55128 Mainz Germany
4	Johannes Gutenberg University 55090 Mainz Germany
5	Helmholtz Institute Mainz GSI Helmholtzzentrum für Schwerionenforschung GmbH 55128 Mainz Germany
6	University of California Berkeley Berkeley CA 94720 USA
7	University of California Berkeley, Berkeley, CA, 94720 USA

We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectroscopic resolution using zero-field nuclear magnetic resonance spectroscopy. This is possible because magnetic susceptibility broadening is negligible at ultralow magnetic fields. We show the two-step hydrogenation of dimethyl acetylenedicarboxylate with para-enriched hydrogen gas in conventional glass NMR tubes, as well as in a titanium tube. The low frequency zero-field NMR signals ensure that there is no significant signal attenuation arising from shielding by the electrically conductive sample container. This method paves the way for in situ monitoring of reactions in complex heterogeneous multiphase systems and in reactors made of conductive materials while maintaining resolution and chemical specificity.

Burueva D.B. , Eills J. , Blanchard J.W. , Garcon A. , Picazo‐Frutos R. , Kovtunov K.V. , Koptyug I.V. , Budker D.
Chemical Reaction Monitoring using Zero‐Field Nuclear Magnetic Resonance Enables Study of Heterogeneous Samples in Metal Containers
Angewandte Chemie - International Edition. 2020. V.59. N39. P.17026-17032. DOI: 10.1002/anie.202006266 WOS Scopus

Published online:	Jun 8, 2020
Published print:	Sep 21, 2020

Web of science:	WOS:000563902300001
Scopus:	2-s2.0-85088515698

DB	Citing
Scopus	35
Web of science	35