Subsecond Three-Dimensional Nitrogen-15 Magnetic Resonance Imaging Facilitated by Parahydrogen-Based Hyperpolarization

Subsecond Three-Dimensional Nitrogen-15 Magnetic Resonance Imaging Facilitated by Parahydrogen-Based Hyperpolarization Научная публикация

Журнал

The Journal of Physical Chemistry Letters
ISSN: 1948-7185

Вых. Данные

Год: 2022, Том: 13, Номер: 44, Страницы: 10253-10260 Страниц : 8 DOI: 10.1021/acs.jpclett.2c02705

Авторы

Trepakova Alexandra I. ^1,2,3 , Skovpin Ivan V. ¹ , Chukanov Nikita V. ^1,3 , Salnikov Oleg G. ¹ , Chekmenev Eduard Y. ^4,5 , Pravdivtsev Andrey N. ⁶ , Hövener Jan-Bernd ⁶ , Koptyug Igor V. ¹

Организации

1	International Tomography Center, SB RAS, 3A Institutskaya Street, Novosibirsk630090, Russia
2	Institute of Cytology and Genetics, SB RAS, 10 Acad. Lavrentiev Avenue, Novosibirsk630090, Russia
3	Novosibirsk State University, 2 Pirogova Street, Novosibirsk630090, Russia
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan48202, United States
5	Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, Moscow119991, Russia
6	Department of Radiology and Neuroradiology Section Biomedical Imaging, MOIN CC, Universitätsklinikum Schleswig-Holstein, Universität Kiel, 14 Am Botanischen Garten, Kiel24118, Germany

Magnetic resonance imaging (MRI) provides unique information about the internal structure and function of living organisms in a non-invasive way. The use of conventional proton MRI for the observation of real-time metabolism is hampered by the dominant signals of water and fat, which are abundant in living organisms. Heteronuclear MRI in conjunction with the hyperpolarization methods does not encounter this issue. In this work, we polarized 15N nuclei of [15N1]fampridine (a drug used for the treatment of multiple sclerosis) to the level of 4% in nuclear magnetic resonance (NMR) experiments and 0.7% in MRI studies using spin-lock-induced crossing combined with signal amplification by reversible exchange. Consequently, three-dimensional 15N MRI of the hyperpolarized 15N-labeled drug was acquired in 0.1 s with a signal-to-noise ratio of 70. In addition, the NMR signal enhancements for 15N-enriched fampridine and fampridine with a natural abundance of 15N nuclei were compared and an explanation for their difference was proposed.

Trepakova A.I. , Skovpin I.V. , Chukanov N.V. , Salnikov O.G. , Chekmenev E.Y. , Pravdivtsev A.N. , Hövener J-B. , Koptyug I.V.
Subsecond Three-Dimensional Nitrogen-15 Magnetic Resonance Imaging Facilitated by Parahydrogen-Based Hyperpolarization
The Journal of Physical Chemistry Letters. 2022. V.13. N44. P.10253-10260. DOI: 10.1021/acs.jpclett.2c02705 WOS Scopus OpenAlex

Поступила в редакцию:	1 сент. 2022 г.
Принята к публикации:	24 окт. 2022 г.
Опубликована online:	27 окт. 2022 г.
Опубликована в печати:	10 нояб. 2022 г.

Web of science:	WOS:000879554700001
Scopus:	2-s2.0-85141480389
OpenAlex:	W4307428119

БД	Цитирований
Scopus	4
Web of science	2