Neurovascular Coupling: Physiological Foundations, Assessment Methods, and Post-Stroke Changes

Neurovascular Coupling: Physiological Foundations, Assessment Methods, and Post-Stroke Changes Review

Journal

Human Physiology
ISSN: 0362-1197

Output data

Year: 2025, Volume: 51, Number: 6, Pages: 720-728 Pages count : 9 DOI: 10.1134/S036211972570094X

Tags

neurovascular coupling, neurovascular uncoupling, neurovascular unit, stroke, functional magnetic resonance imaging (fMRI), arterial spin labeling (ASL)

Authors

Abramova V.D. ^1,2 , Petrovskii E.D. ¹ , Korostyshevskaya A.M. ¹ , Savelov A.A. ¹

Affiliations

1	International Tomography Center, Siberian Branch, Russian Academy of Sciences (SB RAS), Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia

The aim of this article is to summarize current knowledge on the physiological basis of neurovascular coupling, highlight key aspects of its disruption in stroke, and consider the potential of integrating functional magnetic resonance imaging and arterial spin labeling methods for assessing these processes. The article describes in detail the mechanism of neurovascular coupling under normal conditions, as well as the impact of stroke on neurovascular uncoupling in the lesion site and in intact brain regions. Special attention is given to the use of functional MRI and arterial spin labeling as tools for evaluating perfusion changes and neuronal activity. Recent studies are reviewed to illustrate their application in clinical and research contexts, with an assessment of the strengths and limitations of these techniques in characterizing neurovascular coupling. The prospects of integrating these approaches for comprehensive assessment and monitoring of neurovascular coupling, and for the development of therapeutic strategies aimed at restoring neurovascular interactions in stroke patients, are discussed. This article provides a scientific basis for further studies in functional, quantitative, and noninvasive neuroimaging with a focus on evaluating neurovascular impairments.

Abramova V.D. , Petrovskii E.D. , Korostyshevskaya A.M. , Savelov A.A.
Neurovascular Coupling: Physiological Foundations, Assessment Methods, and Post-Stroke Changes
Human Physiology. 2025. V.51. N6. P.720-728. DOI: 10.1134/S036211972570094X OpenAlex

Абрамова В.Д. , Петровский Е.Д. , Коростышевская А.М. , Савелов А.А.
Функциональное нейроваскулярное взаимодействие: физиологические основы, методы оценки, изменения в постинсультном периоде
Физиология человека. 2025. Т.51. №6. С.181-194. DOI: 10.7868/S3034615025060144

Submitted:	Mar 5, 2025
Accepted:	Sep 16, 2025

≡ OpenAlex:

W7147009360