Sequential magnetovortex thermal and Pt-augmented TiO2 sonodynamics achieve bursting reactive oxygen for imaging guided biofilm associated deep disinfection

Sequential magnetovortex thermal and Pt-augmented TiO2 sonodynamics achieve bursting reactive oxygen for imaging guided biofilm associated deep disinfection Научная публикация

Журнал

Materials and Design
ISSN: 1873-4197

Вых. Данные

Год: 2026, Том: 264, Номер статьи : 115823, Страниц : 13 DOI: 10.1016/j.matdes.2026.115823

Авторы

Zhao Zhiyun ¹ , Wang Ruihua ² , Zhang Jingke ¹ , Feng Haozhan ¹ , Guo Shuangshuang ³ , Wang Jing ⁴ , Song Manli ⁵ , Fan Dandan ³ , Zhuang Yuchuan ⁶ , Li Jing ⁷ , Dong Yanbo ⁸ , Tulupov Andrey ⁹ , Wang Zhengfeng ¹ , Bao Jianfeng ¹

Организации

1	Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
2	Department of Nuclearmedicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
3	School of Basic Medical Sciences, Academy of Medical Sciences, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China
4	School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 71000, China
5	Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
6	Department of Imaging Sciences, University of Rochester Medical Center, Rochester 14627, USA
7	Office of Science and Technology, Henan University of Science and Technology, Luoyang, China
8	Faculty of Teacher Education, Pingdingshan University, Pingdingshan, Henan 467000, China
9	The Laboratory MRT TECHNOLOGIES, The Institute International Tomography Center of the Russian Academy of Sciences, Institutskaya Str. 3A, 630090 Novosibirsk, Russia

Polymicrobial infections and antibiotic-resistant strains often persist within biofilms, where undermine conventional chemotherapies. Here we introduce a sequentially activated antibacterial platform built on magnetic-vortex Fe3O4 nanorings coated with TiO2 and decorated with Pt nanoparticles. This alternating magnetic field (AMF) then ultrasound (US) sequence is designed to reactive oxygen species (ROS) amplification. AMF produces rapid, localized heating that swells biofilm, and increases bacterial envelope permeability. Subsequent US triggers TiO2 sonocatalysis through cavitation and sonoluminescence, generating electron-hole pairs; the Pt-TiO2 Schottky junction selectively traps electrons and suppresses recombination, extending carrier lifetimes and boosting interfacial reaction probability. In parallel, Pt exhibits nanozyme activity that converts endogenous H2O2 into short-lived reactive intermediates, amplifying ROS flux. In vitro, against four bacteria, the platform suppresses planktonic growth and disrupts biofilms with efficient membrane damage. In vivo, in subcutaneous and pulmonary infection models, the AMF → US regimen decreases bacterial burden and accelerates tissue restoration, outperforming multiple comparators while maintaining good biocompatibility and procedural safety. This magnetothermal preheating followed by sonocatalytic amplification establishes an antibiotic-free, imageable paradigm that couple’s biofilm disruption with potent bactericidal action, offering a generalizable engineering route for complex, polymicrobial, and resistance-associated infections.

Zhao Z. , Wang R. , Zhang J. , Feng H. , Guo S. , Wang J. , Song M. , Fan D. , Zhuang Y. , Li J. , Dong Y. , Tulupov A. , Wang Z. , Bao J.
Sequential magnetovortex thermal and Pt-augmented TiO2 sonodynamics achieve bursting reactive oxygen for imaging guided biofilm associated deep disinfection
Materials and Design. 2026. V.264. 115823 :1-13. DOI: 10.1016/j.matdes.2026.115823 OpenAlex

Поступила в редакцию:	5 дек. 2025 г.
Принята к публикации:	10 мар. 2026 г.
Опубликована online:	14 мар. 2026 г.
Опубликована в печати:	16 мар. 2026 г.

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