Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross‐Relaxation Triggers RASER of Solute Molecules

Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross‐Relaxation Triggers RASER of Solute Molecules Full article

Journal

Angewandte Chemie - International Edition
ISSN: 1433-7851

Output data

Year: 2026, Volume: 65, Number: 19, Article number : e2865398, Pages count : 11 DOI: 10.1002/anie.2865398

Authors

Trofimov Ivan A. ¹ , Yi Anna P. ^2,3 , Salnikov Oleg G. ³ , Pravdivtsev Andrey N. ⁴ , de Maissin Henri ^1,5 , Chekmenev Eduard Y. ⁶ , Hövener Jan‐Bernd ⁴ , Schmidt Andreas B. ^1,5,6 , Koptyug Igor V. ³

Affiliations

1	Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
2	Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia
3	International Tomography Center SB RAS, Novosibirsk, Russia
4	Section Biomedical Imaging Molecular Imaging North Competence Center (MOIN CC) Department of Radiology and Neuroradiology University Hospital Schleswig‐Holstein Kiel University Kiel Germany
5	German Cancer Consortium (DKTK), Partner Site Freiburg a Partnership Between DKFZ and University Medical Center Freiburg Heidelberg Germany
6	Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University Detroit Michigan USA

Radiofrequency amplification by stimulated emission of radiation (RASER) is a phenomenon that is observed in systems of nuclear spins with strong inverse polarization beyond the thermal equilibrium. RASER is of fundamental interest and also possesses several features of possible practical importance, such as very narrow NMR lines and background-free detection. However, so far, the effect was limited to molecules directly polarized by corresponding hyperpolarization techniques. In this work, we found that strongly hyperpolarized allylic compounds transferred polarization via nuclear Overhauser effect (NOE) to other solutes, triggering their RASER. In stark contrast to previous observations, the parahydrogen addition and intermolecular NOE transfer engendered RASER (PAINTER) does not require direct hyperpolarization of the target molecule. This way polarized and detected solutes had 10–20 times narrower lines compared to their classical NMR spectra, providing a useful analysis tool for various molecules beyond standard NMR limitations.

Trofimov I.A. , Yi A.P. , Salnikov O.G. , Pravdivtsev A.N. , de Maissin H. , Chekmenev E.Y. , Hövener J. , Schmidt A.B. , Koptyug I.V.
Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross‐Relaxation Triggers RASER of Solute Molecules
Angewandte Chemie - International Edition. 2026. V.65. N19. e2865398 :1-11. DOI: 10.1002/anie.2865398 WOS Scopus OpenAlex

Submitted:	Dec 2, 2025
Published online:	Mar 26, 2026
Published print:	May 4, 2026

≡ Web of science:	WOS:001724329900001
≡ Scopus:	2-s2.0-105034101258
≡ OpenAlex:	W7141652474