Parahydrogen‐Induced Polarization of Amino Acids | Sciact - научная деятельность

Parahydrogen‐Induced Polarization of Amino Acids Научная публикация

Журнал

Angewandte Chemie - International Edition
ISSN: 1433-7851

Вых. Данные

Год: 2021, Том: 60, Номер: 44, Страницы: 23496-23507 Страниц : 12 DOI: 10.1002/anie.202100109

Авторы

Pravdivtsev Andrey N. ¹ , Buntkowsky Gerd ² , Duckett Simon B. ³ , Koptyug Igor V. ^4,5 , Hövener Jan‐Bernd ¹

Организации

1	Section Biomedical Imaging Molecular Imaging North Competence Center (MOIN CC) Department of Radiology and Neuroradiology University Medical Center Schleswig-Holstein (UKSH) Kiel University Am Botanischen Garten 14 24118 Kiel Germany
2	Technical University Darmstadt Eduard-Zintl-Institute for Inorganic and Physical Chemistry Alarich-Weiss-Strasse 8 64287 Darmstadt Germany
3	Department Center for Hyperpolarization in Magnetic Resonance (CHyM) Department of Chemistry University of York, Heslington York YO10 5NY UK
4	International Tomography Center SB RAS 3A Institutskaya st. 630090 Novosibirsk Russia
5	Novosibirsk State University 2 Pirogova st. 630090 Novosibirsk Russia

Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.

Pravdivtsev A.N. , Buntkowsky G. , Duckett S.B. , Koptyug I.V. , Hövener J.
Parahydrogen‐Induced Polarization of Amino Acids
Angewandte Chemie - International Edition. 2021. V.60. N44. P.23496-23507. DOI: 10.1002/anie.202100109 WOS Scopus OpenAlex

Поступила в редакцию:	4 янв. 2021 г.
Опубликована online:	26 февр. 2021 г.
Опубликована в печати:	13 авг. 2021 г.

≡ Web of science:	WOS:000684732000001
≡ Scopus:	2-s2.0-85108795518
≡ OpenAlex:	W3130270118