Smart single hollow magnetothermal nanorings with phase change materials for controlled drug release and negative MRI guided cancer therapy

Smart single hollow magnetothermal nanorings with phase change materials for controlled drug release and negative MRI guided cancer therapy Full article

Journal

International Journal of Pharmaceutics
ISSN: 1873-3476

Output data

Year: 2026, Volume: 700, Article number : 127042, Pages count : 14 DOI: 10.1016/j.ijpharm.2026.127042

Tags

Phase change materials; Controlled drug release; Magnetichyperthermia; Magnetic resonance imaging; Theranostics

Authors

Bao Jianfeng ¹ , Guo Shuangshuang ² , Ren Yanan ¹ , Cheng Junying ¹ , Yang Yuhao ² , Zhang Yuanyuan ^3,2 , Tu Hui ⁴ , Wang Jing ⁴ , Fan Dandan ² , Zhuang Yuchuan ⁵ , Dong Yanbo ⁶ , Tulupov Andrey ⁷ , Wang Xiao ⁸ , Ma Xiaoyue ⁹ , Zhang Yong ^3,2

Affiliations

1	Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
2	School of Basic Medical Sciences, Academy of Medical Sciences, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China
3	Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China. Electronic address: zzuzhangyong2013@163.com
4	School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China
5	Department of Imaging Sciences, University of Rochester Medical Center, Rochester 14627, USA
6	Faculty of Teacher Education, Pingdingshan University, Pingdingshan, Henan 467000, China
7	The Laboratory MRT TECHNOLOGIES, The Institute International Tomography Center of the Russian Academy of Sciences, Institutskaya Str. 3A, 630090 Novosibirsk, Russia
8	Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China. Electronic address: daisywangxiao@outlook.com
9	Functional Magnetic Resonance and Molecular Imaging Key Laboratory of Henan Province, Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China. Electronic address: maxiaoyue0822@163.com

Magnetic hyperthermia therapy (MHT) for tumors is alocalized, minimally invasive, and deeply penetrating treatment, but it faces limitations such as low magnetothermal conversion efficiency, strict safety thresholds for magnetic field intensity, and the inability of single-mode magnetic hyperthermia to completely eradicate tumors. In this work, we develop an innovative, thermoresponsive drug-delivery platform composed of single hollow magnetic vortex iron oxide nanorings (MVIONs) coated with phase-change materials (PCM), designated MVIONs@PCM. Under an alternating magnetic field (AMF), MVIONs efficiently generate heat, triggering the melting of the PCM shell and releasing co-encapsulated anticancer drugs in a controlled, “on/off” manner. In vitro experiments confirm the exceptional thermal induction capacity of MVIONs@PCM, yielding a specific absorption rate of 1058.68 W·g−1 at 600 Oe, sufficient to produce robust hyperthermia effects. Additionally, this nano platform exhibits very low basal release without AMF activation. MVIONs@PCM also achieves strong negative magnetic resonance imaging (MRI) contrast, with a high transverse relaxivity (R2 = 45.986 mM−1·s−1) even at 0.5 T, supporting real-time treatment guidance and monitoring. Combining magnetic hyperthermia and AMF-induced chemotherapy significantly enhances tumor growth inhibition. This multifunctional platform represents a promising strategy for MRI-guided magnetothermal chemotherapy

Bao J. , Guo S. , Ren Y. , Cheng J. , Yang Y. , Zhang Y. , Tu H. , Wang J. , Fan D. , Zhuang Y. , Dong Y. , Tulupov A. , Wang X. , Ma X. , Zhang Y.
Smart single hollow magnetothermal nanorings with phase change materials for controlled drug release and negative MRI guided cancer therapy
International Journal of Pharmaceutics. 2026. V.700. 127042 :1-14. DOI: 10.1016/j.ijpharm.2026.127042 WOS Scopus OpenAlex

Submitted:	Jan 8, 2026
Accepted:	May 30, 2026
Published online:	Jun 4, 2026
Published print:	Jul 10, 2026

≡ Web of science:	WOS:001798920900001
≡ Scopus:	2-s2.0-105042046103
≡ OpenAlex:	W7163565465