Реферат: Nuclear spin hyperpolarization boosts NMR sensitivity but typically requires complex infrastructure. Signal Amplification by Reversible Exchange (SABRE), a parahydrogen-based hyperpolarization technique, can be conducted using a remarkably low-cost polarizer (<$100) comprising only magnetic coils and a standard PC sound card, avoiding magnetic shielding. However, under these conditions, SABRE requires direct spin-coupling between parahydrogen and the target nucleus, limiting its application to distant heteronuclear spins such as 77Se in biologically relevant selenium−nitrogen heterocycles (e.g., antioxidant, antiviral, and anticancer agents). Here, we overcome the distance restrictions by developing 15N-mediated polarization transfer driven by oscillating magnetic fields of the audio frequency. As a proof-of-concept, we achieve a 11600-fold enhancement of the 77Se NMR signal (>6% net polarization) at 9.4 T in a shielding-free setup using a selenadiazole derivative. These results suggest that selenadiazole-based compounds are particularly well suited for this strategy and provide a basis for extending it to other selenium-containing molecules.

Библиографическая ссылка: Markelov D.A. , Kiryutin A.S. , Borisov A.V. , Kosenko I.D. , Godovikov I.A. , Yurkovskaya A.V.
77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT
The Journal of Physical Chemistry Letters. 2025. V.16. N41. P.10621-10626. DOI: 10.1021/acs.jpclett.5c02693 WOS Scopus OpenAlex

Даты:

Поступила в редакцию:	29 авг. 2025 г.
Принята к публикации:	1 окт. 2025 г.
Опубликована online:	6 окт. 2025 г.
Опубликована в печати:	16 окт. 2025 г.

Идентификаторы БД:

Web of science:	WOS:001588962500001
Scopus:	2-s2.0-105018669184
OpenAlex:	W4414848049

Цитирование в БД:

БД	Цитирований
Web of science	1
Scopus	1

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