77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT

77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT Full article

Journal

The Journal of Physical Chemistry Letters
ISSN: 1948-7185

Output data

Year: 2025, Volume: 16, Number: 41, Pages: 10621-10626 Pages count : 6 DOI: 10.1021/acs.jpclett.5c02693

Authors

Markelov Danil A. ¹ , Kiryutin Alexey S. ¹ , Borisov Alexander V. ² , Kosenko Irina D. ³ , Godovikov Ivan A. ³ , Yurkovskaya Alexandra V. ¹

Affiliations

1	International Tomography Center, Siberian Branch of the Russian Academy of Science, Institutskaya 3A, Novosibirsk 630090, Russia
2	R.E. Alekseev Nizhny Novgorod State Technical University
3	Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Science, Vavilova 28/1, Moscow 119334, Russia

Nuclear spin hyperpolarization boosts NMR sensitivity but typically requires complex infrastructure. Signal Amplification by Reversible Exchange (SABRE), a parahydrogen-based hyperpolarization technique, can be conducted using a remarkably low-cost polarizer (<$100) comprising only magnetic coils and a standard PC sound card, avoiding magnetic shielding. However, under these conditions, SABRE requires direct spin-coupling between parahydrogen and the target nucleus, limiting its application to distant heteronuclear spins such as 77Se in biologically relevant selenium−nitrogen heterocycles (e.g., antioxidant, antiviral, and anticancer agents). Here, we overcome the distance restrictions by developing 15N-mediated polarization transfer driven by oscillating magnetic fields of the audio frequency. As a proof-of-concept, we achieve a 11600-fold enhancement of the 77Se NMR signal (>6% net polarization) at 9.4 T in a shielding-free setup using a selenadiazole derivative. These results suggest that selenadiazole-based compounds are particularly well suited for this strategy and provide a basis for extending it to other selenium-containing molecules.

Markelov D.A. , Kiryutin A.S. , Borisov A.V. , Kosenko I.D. , Godovikov I.A. , Yurkovskaya A.V.
77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT
The Journal of Physical Chemistry Letters. 2025. V.16. N41. P.10621-10626. DOI: 10.1021/acs.jpclett.5c02693 WOS OpenAlex

Submitted:	Aug 29, 2025
Accepted:	Oct 1, 2025
Published online:	Oct 6, 2025
Published print:	Oct 16, 2025

Web of science:	WOS:001588962500001
OpenAlex:	W4414848049

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